Tromethamine hydrochloride

CAS 1185-53-1

U.S. production volumes are classified as confidential business information.

Molecular structure of 1185-53-1 — 1 HCl

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$197M

Top sourceChina 36%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292219 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 292219, which covers 167 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 36%ChinaIT 15%ItalyDE 14%GermanyIN 7%IndiaHU 5%Hungary

Saudi Arabia
Lithuania
Canada
Ukraine
Israel
Singapore
Mexico
Ireland
Netherlands
Malaysia
Slovakia
Denmark
Finland
Latvia
Greece
Austria

EPA-registered manufacturers (2)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Angus Chemical

Avantor

Why It Matters

Sectors

HealthConsumer ProductsCore Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Stabilizing agent in Pharmaceutical and Medicine Manufacturing (94%)Processing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS1185-53-1

PubChem CID93573

DTXSIDDTXSID4044373

FormulaC4H12ClNO3

Mol. Weight157.59 g/mol

SMILESC(C(CO)(CO)N)O.Cl

Data Sources

EPA CompTox (DSSTox) · DTXSID4044373Retrieved 2026-04-06
PubChem · compound 93573Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Tromethamine hydrochloride (CAS 1185-53-1) https://chemicalindependence.com/chemical/1185-53-1/ EPA CompTox (DSSTox): DTXSID4044373. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID4044373 PubChem: 93573. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/93573 EPA Chemical Data Reporting: 1185-53-1. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 1185-53-1. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 292219 for CAS 1185-53-1. Reporting year: 2024. https://usatrade.census.gov/