zoledronic acid

Drug ingredient

CAS 118072-93-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$114M

Top sourceChina 26%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293329 · basket

These shares come from HS customs code 293329, which covers 173 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 26%ChinaIN 17%IndiaKR 16%South KoreaDE 9%GermanyIT 9%Italy

Australia
Brazil
Czech Republic
Ireland
Sweden
Ukraine
Poland
United Arab Emirates
Hungary
Israel
Netherlands
Canada
Saudi Arabia
Greece
Belgium
Austria
Latvia
Singapore
Denmark

31 FDA-registered drug labelers

Accord Healthcare Inc.

Assia Chemical Industries Ltd - Teva Tech Site

AuroMedics Pharma LLC

Avenacy Inc.

BluePoint Laboratories

BPI Labs LLC

Dr. Reddy's Laboratories Inc

Dr. Reddy's Laboratories Limited

Dr.Reddy's Laboratories Ltd

Emcure Pharmaceuticals Limited

Eugia US LLC

FOSUN PHARMA USA INC

Fresenius Kabi USA, LLC

Gador S.A.

Gland Pharma Limited

Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals Inc.

Hetero Labs Limited

Hikma Pharmaceuticals USA Inc.

Maprimed S.A.

Meitheal Pharmaceuticals Inc.

Mylan Institutional LLC

Natco Pharma Limited

NORTHSTAR RX LLC

Sagent Pharmaceuticals

Sandoz Inc

ScinoPharm Taiwan Ltd.

SHILPA PHARMA LIFESCIENCES LIMITED

SUN PHARMACEUTICAL INDUSTRIES, INC.

USV Private Limited

Westminster Pharmaceuticals, LLC

Yung Shin Pharmaceutical Ind. Co., Ltd.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•zoledronic acid
•Reclast

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS118072-93-8

PubChem CID68740

DTXSIDDTXSID0042668

FormulaC5H10N2O7P2

Mol. Weight272.09 g/mol

SMILESC1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O

Data Sources

PubChem · compound 68740Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

zoledronic acid (CAS 118072-93-8) https://chemicalindependence.com/chemical/118072-93-8/ PubChem: 68740. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/68740 FDA National Drug Code directory: CAS 118072-93-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293329 for CAS 118072-93-8. Reporting year: 2024. https://usatrade.census.gov/