flurazepam hydrochloride

Drug ingredientActive Shortage

CAS 1172-18-5

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

Molecular structure of 1172-18-5 — 2 HCl

US productionNot reported

Import value, 2024$10M

Top sourceItaly 73%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293391 · basket

These shares come from HS customs code 293391, which covers 14 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 73%ItalyIN 21%IndiaIL 4%IsraelFI 1%Finland

China
Switzerland
Germany

3 FDA-registered drug labelers

Cambrex Profarmaco Milano Srl

Chartwell RX, LLC

F.I.S. FABBRICA ITALIANA SINTETICI S.P.A.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Flurazepam Hydrochloride

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Flurazepam Hydrochloride Capsule
Shortage listed since August 3, 2022
Manufacturer reports: 1 unavailable, 1 available

See all current drug shortages

Chemical Identity

CAS1172-18-5

PubChem CID14434

DTXSIDDTXSID3025334

FormulaC21H25Cl3FN3O

Mol. Weight460.8 g/mol

SMILESCCN(CC)CCN1C(=O)CN=C(C2=C1C=CC(=C2)Cl)C3=CC=CC=C3F.Cl.Cl

Data Sources

PubChem · compound 14434Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

flurazepam hydrochloride (CAS 1172-18-5) https://chemicalindependence.com/chemical/1172-18-5/ PubChem: 14434. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/14434 FDA National Drug Code directory: CAS 1172-18-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 1172-18-5. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293391 for CAS 1172-18-5. Reporting year: 2024. https://usatrade.census.gov/