1,1,1,3,3,3-Hexachloro-2-propanone

CAS 116-16-5

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$175M

Top sourceIndia 48%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291479 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291479, which covers 95 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 48%IndiaCN 20%ChinaMX 19%MexicoDE 10%GermanyFI 2%Finland

Ukraine
Japan
Australia
Netherlands
South Korea
Canada
Switzerland
Russia
Poland
Italy
United Kingdom
Spain
Taiwan
Grenada

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Wacker Chemical Corporation - Headquarters

Why It Matters

Sectors

HealthMetals & Mining

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 2 sectors as 1 functional role.

•Intermediate in Pharmaceutical and Medicine ManufacturingProcessing as a reactant
•Intermediate in Miscellaneous ManufacturingProcessing as a reactant

Vendor Pricing

$0.03/gSigma-Aldrich (Rush Stock)

CountryGermany

Pack$10216.38 / 330 kg

Purity99%

Vendors9 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

8 more vendors

Vendor	Country	$/g	Pack	Purity
Sigma-Aldrich	Germany	$0.03	330 kg	99%
A2B Chem LLC	United States	$0.11	500 g	99%
ALFA AESAR	Germany	$0.12	1 kg	99%
AA BLOCKS	United States	$0.13	500 g	99%
AK Scientific, Inc.	United States	$0.68	100 g	98%
Fulfilled by Molport	Latvia	$2.00	5 g	—
Otava, Ltd.	Ukraine	$2280.00	50 mg	95%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	95%

Chemical Identity

CAS116-16-5

PubChem CID8303

DTXSIDDTXSID7021601

FormulaC3Cl6O

Mol. Weight264.7 g/mol

SMILESC(=O)(C(Cl)(Cl)Cl)C(Cl)(Cl)Cl

Data Sources

EPA CompTox (DSSTox) · DTXSID7021601Retrieved 2026-04-06
PubChem · compound 8303Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

1,1,1,3,3,3-Hexachloro-2-propanone (CAS 116-16-5) https://chemicalindependence.com/chemical/116-16-5/ EPA CompTox (DSSTox): DTXSID7021601. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID7021601 PubChem: 8303. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/8303 EPA Chemical Data Reporting: 116-16-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 116-16-5. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291479 for CAS 116-16-5. Reporting year: 2024. https://usatrade.census.gov/