Cabozantinib S-malate

Drug ingredient

CAS 1140909-48-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$111M

Top sourceIndia 28%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293349 · basket

These shares come from HS customs code 293349, which covers 94 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 28%IndiaCN 27%ChinaSE 12%SwedenKR 10%South KoreaGB 4%United Kingdom

Spain
Portugal
Germany
Netherlands
Israel
Australia
Taiwan
Lithuania
South Africa
Hong Kong

9 FDA-registered drug labelers

Biocon Limited

ESCIENTIA ADVANCED SCIENCES PRIVATE LIMITED

Exelixis, Inc.

MSN Laboratories Private Limited

Piramal Healthcare (Canada) Limited

PPL Pharma Solutions Riverview LLC

Shanghai Huilun Jiangsu Pharmaceutical Co., Ltd.

Sterling Chemical Malta Ltd

Valary Lab Private Limited

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Cabometyx
•Cometriq

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS1140909-48-3

PubChem CID25102846

DTXSIDDTXSID60915949

FormulaC32H30FN3O10

Mol. Weight635.6 g/mol

SMILESCOC1=CC2=C(C=CN=C2C=C1OC)OC3=CC=C(C=C3)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F.C(C(C(=O)O)O)C(=O)O

Data Sources

PubChem · compound 25102846Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

← Back to Dashboard ← Back to Health

Brief citations

Cabozantinib S-malate (CAS 1140909-48-3) https://chemicalindependence.com/chemical/1140909-48-3/ PubChem: 25102846. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/25102846 FDA National Drug Code directory: CAS 1140909-48-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293349 for CAS 1140909-48-3. Reporting year: 2024. https://usatrade.census.gov/