Penicillin G potassium

Drug ingredient

CAS 113-98-4

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$78M

Top sourceItaly 33%

EPA lists this chemical for 2019 but publishes zero or no volume for both production and imports.

Why supply is unknown

Production is reported production, not a complete census of factories. Production reporting year: 2019. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 294110 · basket

EPA reports by year

2019: US production Not published · Imports Not published

These shares come from HS customs code 294110, which covers 13 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IT 33%ItalyCN 31%ChinaBG 22%BulgariaES 8%SpainMX 3%Mexico

Singapore
Israel
Germany
South Korea
Hong Kong
Japan
Switzerland

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Mitsui & Co. (U. S. A.)

12 FDA-registered drug labelers

ACS Dobfar S.p.A

Athenex Pharmaceutical Division, LLC.

Avenacy Inc.

Baxter Healthcare Corporation

HF Acquisition Co LLC, DBA HealthFirst

North China Pharmaceutical Co., Ltd. Beta Branch Factory

NorthStar Rx, LLC

Roerig

Sagent Pharmaceuticals

Sandoz Inc

Sinopharm Weiqida Pharmaceutical Co., Ltd.

WG Critical Care, LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Penicillin G Potassium
•Pfizerpen
•Buffered Penicillin G Potassium

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS113-98-4

PubChem CID23664709

DTXSIDDTXSID7045106

FormulaC16H17KN2O4S

Mol. Weight372.5 g/mol

SMILESCC1(C(N2C(S1)C(C2=O)NC(=O)CC3=CC=CC=C3)C(=O)[O-])C.[K+]

Data Sources

EPA CompTox (DSSTox) · DTXSID7045106Retrieved 2026-04-06
PubChem · compound 23664709Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Penicillin G potassium (CAS 113-98-4) https://chemicalindependence.com/chemical/113-98-4/ EPA CompTox (DSSTox): DTXSID7045106. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID7045106 PubChem: 23664709. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/23664709 EPA Chemical Data Reporting: 113-98-4. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: CAS 113-98-4. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 294110 for CAS 113-98-4. Reporting year: 2024. https://usatrade.census.gov/