Imipramine hydrochloride

Drug ingredient

CAS 113-52-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 113-52-0
1 HCl
US productionNot reported
Import value, 2024$1.4B
Top sourceIreland 33%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293399 · basket

These shares come from HS customs code 293399, which covers 518 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 33%IrelandCN 26%ChinaIN 11%IndiaDE 9%GermanyIT 4%Italy
18 FDA-registered drug labelers
A-S Medication Solutions
Advanced Rx Pharmacy of Tennessee, LLC
Bryant Ranch Prepack
Coupler LLC
Key Therapeutics
Leading Pharma, LLC
Lupin Pharmaceuticals, Inc.
Medisca Inc.
NuCare Pharmaceuticals, Inc.
Oxford Pharmaceuticals, LLC
PD-Rx Pharmaceuticals, Inc.
Professional Compounding Centers of America dba PCCA
Proficient Rx LP
R.L.Fine Chem Private Limited
REMEDYREPACK INC.
Spectrum Laboratory Products, Inc.
Strides Pharma Science Limited
Teva API India Private Ltd

Why It Matters

Sectors
Health
Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

  • •Imipramine Hydrochloride
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$5.82/gSigma-Aldrich (Rush Stock)
CountryGermany
Pack$582.26 / 100 g
Purity99%
Vendors28 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS113-52-0
PubChem CID8228
DTXSIDDTXSID7040738
FormulaC19H25ClN2
Mol. Weight316.9 g/mol
SMILESCN(C)CCCN1C2=CC=CC=C2CCC3=CC=CC=C31.Cl

Data Sources

Brief citations

Imipramine hydrochloride (CAS 113-52-0) https://chemicalindependence.com/chemical/113-52-0/ PubChem: 8228. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/8228 EPA TSCA Inventory: CAS 113-52-0. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293399 for CAS 113-52-0. Reporting year: 2024. https://usatrade.census.gov/