Methylphenidate

Drug ingredientActive Shortage

CAS 113-45-1

This drug ingredient is in active FDA shortage. At least one manufacturer cannot meet demand.

US productionNot reported

Import value, 2024$2M

Top sourceSwitzerland 86%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293333 · basket

These shares come from HS customs code 293333, which covers 11 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CH 86%SwitzerlandCN 11%ChinaIT 1%ItalyUA 1%Ukraine

India
Brazil
Latvia

10 FDA-registered drug labelers

Ascent Pharmaceuticals, Inc.

Cambrex Charles City, Inc

Chattem Chemicals, Inc.

Coating Place, LLC

Mylan Pharmaceuticals Inc.

Neos Therapeutics Brands, LLC

Noven Therapeutics, LLC

PADAGIS US LLC

SpecGx LLC

Veranova, L.P.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 5 drug and cosmetic product listings (FDA).

•Methylphenidate Transdermal System
•Daytrana
•Cotempla XR-ODT
•Methylphenidate
•Methylphenidate Hydrochloride

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

Active Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

Current shortage
Methylphenidate Hydrochloride Tablet, Extended Release
Shortage listed since July 26, 2023
Manufacturer reports: 1 unavailable, 1 limited, 1 available
Current shortage
Methylphenidate Film, Extended Release
Shortage listed since February 28, 2025
Manufacturer reports: 1 available

See all current drug shortages

Chemical Identity

CAS113-45-1

PubChem CID4158

DTXSIDDTXSID5023299

FormulaC14H19NO2

Mol. Weight233.31 g/mol

SMILESCOC(=O)C(C1CCCCN1)C2=CC=CC=C2

Data Sources

PubChem · compound 4158Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Methylphenidate (CAS 113-45-1) https://chemicalindependence.com/chemical/113-45-1/ PubChem: 4158. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/4158 FDA National Drug Code directory: CAS 113-45-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 113-45-1. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 293333 for CAS 113-45-1. Reporting year: 2024. https://usatrade.census.gov/