letrozole

Drug ingredient

CAS 112809-51-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$1.4B

Top sourceIreland 33%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293399 · basket

These shares come from HS customs code 293399, which covers 518 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 33%IrelandCN 26%ChinaIN 11%IndiaDE 9%GermanyIT 4%Italy

Taiwan
Poland
Canada
Ivory Coast
Greece
Hungary
Indonesia
Latvia
Belgium
Slovakia
Czech Republic
Austria
Netherlands
Finland
Denmark
Croatia
Australia
South Africa
Sweden
Hong Kong
Malta
Singapore
Lithuania
Malaysia
Oman
Serbia

27 FDA-registered drug labelers

A-S Medication Solutions

Accord Healthcare, Inc.

ATLANTIC BIOLOGICALS CORP.

Aurobindo Pharma Limited

Avet Pharmaceuticals Inc.

AvKARE

AvPAK

Breckenridge Pharmaceutical, Inc.

Bryant Ranch Prepack

Catalent Micron Technologies, Inc.

Chartwell RX, LLC

Dr. Reddy's Laboratories Limited

Golden State Medical Supply, Inc.

Hetero Labs Limited

Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Natco Pharma Limited

Novartis Pharma Stein AG

Novartis Pharmaceuticals Corporation

NuCare Pharmaceuticals,Inc.

Proficient Rx LP

ScinoPharm Taiwan Ltd.

Sicor de Mexico S.A. de C.V

SUN PHARMACEUTICAL INDUSTRIES, INC.

Synthimed Labs Private Limited

Teva Pharmaceuticals USA, Inc.

Upsher-Smith Laboratories, LLC

Yiling Pharmaceutical, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Letrozole
•Femara

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS112809-51-5

PubChem CID3902

DTXSIDDTXSID4023202

FormulaC17H11N5

Mol. Weight285.3 g/mol

SMILESC1=CC(=CC=C1C#N)C(C2=CC=C(C=C2)C#N)N3C=NC=N3

Data Sources

PubChem · compound 3902Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

letrozole (CAS 112809-51-5) https://chemicalindependence.com/chemical/112809-51-5/ PubChem: 3902. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/3902 FDA National Drug Code directory: CAS 112809-51-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293399 for CAS 112809-51-5. Reporting year: 2024. https://usatrade.census.gov/