Ponatinib hydrochloride

Drug ingredient

CAS 1114544-31-8

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 1114544-31-8 — 1 HCl

US productionNot reported

Import value, 2024$7.6B

Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India

Israel
Bulgaria
Japan
Spain
Sweden
Canada
Taiwan
Finland
Portugal
Mexico
Belgium
Hungary
Austria
Brazil
Ukraine
Croatia
Malta
South Korea
South Africa
Denmark
Czech Republic
Malaysia
Argentina
Poland
Cameroon
Australia
Hong Kong
Slovakia
Latvia

5 FDA-registered drug labelers

Apicore Pharmaceuticals Private Limited

MSN Laboratories Private Limited

PPL Pharma Solutions Riverview LLC

Takeda Pharmaceuticals America, Inc.

Zhejiang Lepu Pharmaceutical Co., Ltd.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Iclusig

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$52.60/gAaron Chemicals LLC

CountryHong Kong

Pack$263.00 / 5 g

Purity99%

Vendors13 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

12 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$53.20	5 g	99%
Combi-Blocks, Inc.	United States	$56.00	5 g	95%
Ambeed, Inc.	United States	$66.60	5 g	99%
A2B Chem LLC	United States	$73.00	1 g	99%
AA BLOCKS	United States	$81.00	1 g	99%
MedKoo Biosciences, Inc	United States	$165.00	10 g	98%
Cayman Europe	Estonia	$829.43	1 g	98%
TargetMol Chemicals	China → United States	$866.00	500 mg	99.99%
TargetMol Chemicals US	United States	$1275.00	200 mg	99.99%
MedChemExpress MCE	Sweden	$2625.70	100 mg	99.76%
Angene International Limited	United States	$4070.00	100 mg	98%
Angene	China → Hong Kong	$4266.67	30 mg	99%

Chemical Identity

CAS1114544-31-8

PubChem CID46908927

DTXSIDDTXSID50149655

FormulaC29H28ClF3N6O

Mol. Weight569 g/mol

SMILESCC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5.Cl

Data Sources

PubChem · compound 46908927Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Ponatinib hydrochloride (CAS 1114544-31-8) https://chemicalindependence.com/chemical/1114544-31-8/ PubChem: 46908927. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/46908927 FDA National Drug Code directory: CAS 1114544-31-8. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 1114544-31-8. Reporting year: 2024. https://usatrade.census.gov/