Entrectinib

Drug ingredient

CAS 1108743-60-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$6.4B

Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India

Finland
Netherlands
Canada
Indonesia
Mexico
Taiwan
South Korea
Austria
Croatia
Sweden
Ukraine
Denmark
Israel
Czech Republic
New Zealand
Hong Kong
Kyrgyzstan
Australia
Portugal
South Africa
Poland
Slovenia
Brazil
Slovakia
Vietnam
Latvia
Malta
Hungary
Romania
Kenya
Belarus
Russia
Turkey
Norway

3 FDA-registered drug labelers

Catalent Pharma Solutions, LLC

F. Hoffmann-La Roche Ltd

Genentech, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Rozlytrek

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$211.90/gAngene Chemical

CountryChina (registered: Hong Kong)

Pack$2119.00 / 10 g

Purity98%

Vendors19 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

18 more vendors

Vendor	Country	$/g	Pack	Purity
Aaron Chemicals LLC	Hong Kong	$231.60	5 g	98%
Combi-Blocks, Inc.	United States	$236.00	5 g	95%
BLD Pharmatech Ltd.	China	$270.00	5 g	98%
Excenen Pharmatech Co., Ltd	China	$560.00	1 g	99.13%
MedKoo Biosciences, Inc	United States	$650.00	5 g	98%
A2B Chem LLC	United States	$1082.00	500 mg	98%
BLD Pharmatech Co., Limited	United States	$1352.00	250 mg	98%
BLD Pharmatech GmbH	Germany	$1352.00	250 mg	98%
Ambeed, Inc.	United States	$1352.00	250 mg	98%
AA BLOCKS	United States	$1418.00	500 mg	98%
TargetMol Chemicals	China → United States	$1456.00	500 mg	99.61%
AstaTech, Inc	United States	$2000.00	100 mg	95%
Molnova	China	$2670.00	100 mg	99%
TargetMol Chemicals EU	Austria	$2970.00	100 mg	99.61%
Angene International Limited	United States	$3780.00	100 mg	95%
MedChemExpress MCE	Sweden	$4537.50	100 mg	99.87%
Apexbio Technology LLC	United States	$6630.00	100 mg	98.84%
Cayman Europe	Estonia	$35224.00	10 mg	98%

Chemical Identity

CAS1108743-60-7

PubChem CID25141092

DTXSIDDTXSID101026450

FormulaC31H34F2N6O2

Mol. Weight560.6 g/mol

SMILESCN1CCN(CC1)C2=CC(=C(C=C2)C(=O)NC3=NNC4=C3C=C(C=C4)CC5=CC(=CC(=C5)F)F)NC6CCOCC6

Data Sources

PubChem · compound 25141092Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Entrectinib (CAS 1108743-60-7) https://chemicalindependence.com/chemical/1108743-60-7/ PubChem: 25141092. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/25141092 FDA National Drug Code directory: CAS 1108743-60-7. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 1108743-60-7. Reporting year: 2024. https://usatrade.census.gov/