Paroxetine hydrochloride hemihydrate

Drug ingredient

CAS 110429-35-1

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 110429-35-1 — 2 HCl · 1 H₂O

US productionNot reported

Import value, 2024$6.4B

Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India

Finland
Netherlands
Canada
Indonesia
Mexico
Taiwan
South Korea
Austria
Croatia
Sweden
Ukraine
Denmark
Israel
Czech Republic
New Zealand
Hong Kong
Kyrgyzstan
Australia
Portugal
South Africa
Poland
Slovenia
Brazil
Slovakia
Vietnam
Latvia
Malta
Hungary
Romania
Kenya
Belarus
Russia
Turkey
Norway

39 FDA-registered drug labelers

Advanced Rx Pharmacy of Tennessee, LLC

Alembic Pharmaceuticals Inc.

Alembic Pharmaceuticals Limited

ANI Pharmaceuticals, Inc.

Aphena Pharma Solutions - Tennessee, LLC

Apotex Corp

Asclemed USA, Inc.

Aurobindo Pharma Limited

Aurolife Pharma LLC

AvPAK

Bryant Ranch Prepack

Cadila Pharmaceuticals Limited

Chartwell RX, LLC.

Cutyx Research LLP

DIRECT RX

Jubilant Biosys limited

Lupin Pharmaceuticals, Inc.

MAEDA INC

Matrix Pharmacorp Private Limited

Medichem S.A.

Medisca Inc.

Modavar Pharmaceuticals LLC

Ningbo Vitax Biotech Co., Ltd

NorthStar Rx LLC

NuCare Pharamceuticals, Inc.

NuCare Pharmaceuticals, Inc.

PD-Rx Pharmaceuticals, Inc.

Proficient Rx LP

REMEDYREPACK INC.

Signa S.A. de C.V.

Solco Healthcare US, LLC

St. Mary's Medical Park Pharmacy

SUN PHARMACEUTICAL INDUSTRIES, INC.

ThermoFisher Scientific Cork

Wanbury Limited

Yiling Pharmaceutical, Inc.

ZHEJIANG HUAHAI PHARMACEUTICAL CO., LTD.

Zydus Lifesciences Limited

Zydus Pharmaceuticals USA Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Paroxetine
•Paroxetine Hydrochloride

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Chemical Identity

CAS110429-35-1

PubChem CID5282487

DTXSIDDTXSID101017095

FormulaC38H44Cl2F2N2O7

Mol. Weight749.7 g/mol

SMILESC1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.C1CNCC(C1C2=CC=C(C=C2)F)COC3=CC4=C(C=C3)OCO4.O.Cl.Cl

Data Sources

PubChem · compound 5282487Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

← Back to Dashboard ← Back to Health

Brief citations

Paroxetine hydrochloride hemihydrate (CAS 110429-35-1) https://chemicalindependence.com/chemical/110429-35-1/ PubChem: 5282487. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5282487 FDA National Drug Code directory: CAS 110429-35-1. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 110429-35-1. Reporting year: 2024. https://usatrade.census.gov/