Aprocitentan

Drug ingredient

CAS 1103522-45-7

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 1103522-45-7
US productionNot reported
Import value, 2024$7.6B
Top sourceIreland 61%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293359 · basket

These shares come from HS customs code 293359, which covers 295 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IE 61%IrelandCH 30%SwitzerlandGB 2%United KingdomCN 2%ChinaIN 1%India
3 FDA-registered drug labelers
Excella GmbH & Co. KG
HOVIONE LLC
Idorsia Pharmaceuticals Ltd

Why It Matters

Sectors
Health
Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

  • •Tryvio
FDA Shortage Status
No FDA shortage records

Vendor Pricing

$1450.00/gAaron Chemicals LLC
CountryHong Kong
Pack$1450.00 / 1 g
Purity98%
Vendors19 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

Chemical Identity

CAS1103522-45-7
PubChem CID25099191
DTXSIDDTXSID401358931
FormulaC16H14Br2N6O4S
Mol. Weight546.2 g/mol
SMILESC1=CC(=CC=C1C2=C(N=CN=C2OCCOC3=NC=C(C=N3)Br)NS(=O)(=O)N)Br

Data Sources

Brief citations

Aprocitentan (CAS 1103522-45-7) https://chemicalindependence.com/chemical/1103522-45-7/ PubChem: 25099191. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/25099191 FDA National Drug Code directory: CAS 1103522-45-7. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293359 for CAS 1103522-45-7. Reporting year: 2024. https://usatrade.census.gov/