Morpholine

CAS 110-91-8

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$6.4B

Top sourceSingapore 36%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India

Finland
Netherlands
Canada
Indonesia
Mexico
Taiwan
South Korea
Austria
Croatia
Sweden
Ukraine
Denmark
Israel
Czech Republic
New Zealand
Hong Kong
Kyrgyzstan
Australia
Portugal
South Africa
Poland
Slovenia
Brazil
Slovakia
Vietnam
Latvia
Malta
Hungary
Romania
Kenya
Belarus
Russia
Turkey
Norway

EPA-registered manufacturers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Nalco- An Ecolab

Domestic parents -- activity not disclosed (5)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Brenntag

Catalynt Solutions

Huntsman

Icl Specialty Products North America

Silver Fern Chemical

EPA-registered importers (4)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Basf Se · DE Germany

Allchem Industries Holding

Basf

Chemical Distribution Network

Why It Matters

Sectors

WaterConsumer ProductsPaper & PrintingCore Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 6 sectors as 5 functional roles.

•Anti-condensation agent in Paper Manufacturing (100%)Processing as a reactant
•Intermediate in All Other Chemical Product and Preparation Manufacturing (100%)Processing as a reactant
•Corrosion inhibitor in Services (100%)Processing as a reactant
•Anti-scaling agent in Utilities (100%)Use—non-incorporative activities
•Intermediate in All Other Basic Organic Chemical ManufacturingProcessing as a reactant
•Abrasives in Soap, Cleaning Compound, and Toilet Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS110-91-8

PubChem CID8083

DTXSIDDTXSID2025688

FormulaC4H9NO

Mol. Weight87.12 g/mol

SMILESC1COCCN1

Data Sources

EPA CompTox (DSSTox) · DTXSID2025688Retrieved 2026-04-06
PubChem · compound 8083Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Morpholine (CAS 110-91-8) https://chemicalindependence.com/chemical/110-91-8/ EPA CompTox (DSSTox): DTXSID2025688. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025688 PubChem: 8083. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/8083 EPA Chemical Data Reporting: 110-91-8. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 110-91-8. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 293499 for CAS 110-91-8. Reporting year: 2024. https://usatrade.census.gov/