1,3,5-Trioxane

CAS 110-88-3

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$2M

Top sourceGermany 48%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291250 · narrow

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291250, which covers 3 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

DE 48%GermanyCH 48%SwitzerlandCN 3%ChinaIT 1%ItalyIN 1%India

Why It Matters

Sectors

Plastics & Rubber

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 1 sector as 2 functional roles.

•Intermediate in Plastics Material and Resin Manufacturing (100%)Processing as a reactant
•Monomers in Plastics Material and Resin Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.06/gSigma-Aldrich (Rush Stock)

CountryGermany

Pack$128.76 / 2 kg

Purity99%

Vendors13 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

12 more vendors

Vendor	Country	$/g	Pack	Purity
Sigma-Aldrich	Germany	$0.06	2 kg	99%
A2B Chem LLC	United States	$0.08	500 g	95%
AA BLOCKS	United States	$0.08	500 g	99%
AK Scientific Specialized	United States	$0.14	500 g	95%
AK Scientific, Inc.	United States	$0.20	500 g	99%
Combi-Blocks, Inc.	United States	$0.25	1 kg	98%
AstaTech, Inc	United States	$0.55	100 g	95%
Fluorochem UK	United Kingdom	$1.49	25 g	99%
Interbioscreen	Hong Kong	$10.00	10 g	95%
Labotest KG	Germany	$217.80	5000 mg	90%
Otava, Ltd.	Ukraine	$2280.00	50 mg	95%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	95%

Chemical Identity

CAS110-88-3

PubChem CID8081

DTXSIDDTXSID4021925

FormulaC3H6O3

Mol. Weight90.08 g/mol

SMILESC1OCOCO1

Data Sources

EPA CompTox (DSSTox) · DTXSID4021925Retrieved 2026-04-06
PubChem · compound 8081Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

← Back to Dashboard ← Back to Plastics & Rubber

Brief citations

1,3,5-Trioxane (CAS 110-88-3) https://chemicalindependence.com/chemical/110-88-3/ EPA CompTox (DSSTox): DTXSID4021925. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID4021925 PubChem: 8081. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/8081 EPA Chemical Data Reporting: 110-88-3. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 110-88-3. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291250 for CAS 110-88-3. Reporting year: 2024. https://usatrade.census.gov/