N,N,N',N'-Tetramethylethylenediamine

CAS 110-18-9

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$119M

Import volume122.8K lb

Top sourceJapan 33%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292129 · basket

EPA reports by year

2023: US production Confidential · Imports 122.8K lb
2019: US production 4.2M lb · Imports 260.0K lb

These shares come from HS customs code 292129, which covers 69 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

JP 33%JapanCA 14%CanadaNL 10%NetherlandsSE 7%SwedenDE 7%Germany

United Arab Emirates
Czech Republic
Mexico
Malaysia
South Korea
Turkey
Norway
Australia
Ukraine
Russia
Spain
Latvia

EPA-registered manufacturers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Buckman Laboratories

EPA-registered importers (2)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Italmatch Chemicals Spa · IT Italy

Italmatch Usa

Why It Matters

Sectors

Metals & MiningPlastics & RubberCore Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 4 sectors as 2 functional roles.

•Intermediate in All Other Basic Organic Chemical Manufacturing (0%)Processing—incorporation into formulation, mixture, or reaction product
•Intermediate in Miscellaneous Manufacturing (25%)Processing as a reactant
•Catalyst in Plastics Material and Resin Manufacturing (25%)Processing as a reactant
•Catalyst in Rubber Product Manufacturing (25%)Processing as a reactant

Vendor Pricing

$0.36/gFluorochem UK

CountryUnited Kingdom

Pack$180.18 / 500 g

Purity98%

Vendors9 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

8 more vendors

Vendor	Country	$/g	Pack	Purity
Combi-Blocks, Inc.	United States	$0.42	500 g	98%
A2B Chem LLC	United States	$0.46	500 g	98%
AA BLOCKS	United States	$0.48	500 g	98%
Interbioscreen	Hong Kong	$10.00	10 g	95%
Labotest KG	Germany	$217.80	5000 mg	90%
Otava, Ltd.	Ukraine	$2280.00	50 mg	95%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	95%
TimTec, LLC (back-ordered)	United States	$32000.00	15 mg	94%

Chemical Identity

CAS110-18-9

PubChem CID8037

DTXSIDDTXSID5026122

FormulaC6H16N2

Mol. Weight116.2 g/mol

SMILESCN(C)CCN(C)C

Data Sources

EPA CompTox (DSSTox) · DTXSID5026122Retrieved 2026-04-06
PubChem · compound 8037Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

N,N,N',N'-Tetramethylethylenediamine (CAS 110-18-9) https://chemicalindependence.com/chemical/110-18-9/ EPA CompTox (DSSTox): DTXSID5026122. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026122 PubChem: 8037. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/8037 EPA Chemical Data Reporting: 110-18-9. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 110-18-9. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 292129 for CAS 110-18-9. Reporting year: 2024. https://usatrade.census.gov/