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Methadone hydrochloride

Drug ingredient

CAS 1095-90-5

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 1095-90-5
1 HCl
US productionNot reported
Import value, 2024$276K
Top sourceItaly 66%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292231 · basket

These shares come from HS customs code 292231, which covers 2 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
IT 66%ItalyDE 30%GermanyCA 2%CanadaIN 2%India
24 FDA-registered drug labelers
American Health Packaging
Ascend Laboratories, LLC
ATLANTIC BIOLOGICALS CORP.
Aurolife Pharma, LLC
Breckenridge Pharmaceutical Inc
Bryant Ranch Prepack
Camber Pharmaceuticals, Inc
Elite Laboratories, Inc.
Epic Pharma, LLC
Hikma Pharmaceuticals USA
Hikma Pharmaceuticals USA Inc.
Lannett Company, Inc.
LETCO MEDICAL, LLC
Long Grove Pharmaceuticals, LLC
Major Pharmaceuticals
Medisca Inc.
Mylan Institutional LLC
Pharma Source Direct, Inc.
Precision Dose, Inc.
Siegfried USA, LLC
SpecGx LLC
Spectrum Laboratory Products, Inc.
VistaPharm, LLC
XLCare Pharmaceuticals, Inc

Why It Matters

Sectors
Health
Downstream Uses

Appears in 6 drug and cosmetic product listings (FDA).

  • •Methadose Dispersible
  • •Methadose Sugar-FREE
  • •Methadone Hydrochloride
  • •Methadose
  • •Methadone Hydrocloride dye-free, sugar-free, unflavored
  • •Diskets
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS1095-90-5
PubChem CID14184
DTXSIDDTXSID2020501
FormulaC21H28ClNO
Mol. Weight345.9 g/mol
SMILESCCC(=O)C(CC(C)N(C)C)(C1=CC=CC=C1)C2=CC=CC=C2.Cl

Data Sources

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Brief citations

Methadone hydrochloride (CAS 1095-90-5) https://chemicalindependence.com/chemical/1095-90-5/ PubChem: 14184. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/14184 FDA National Drug Code directory: CAS 1095-90-5. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292231 for CAS 1095-90-5. Reporting year: 2024. https://usatrade.census.gov/