Tetrahydrofuran
CAS 109-99-9
U.S. production volumes are classified as confidential business information.
US productionCBI
Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.
Import value, 2024$3M
Top sourceTaiwan 27%
At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.
Why supply is unknownProduction is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023.
Where It Comes From
Customs basis: HS 293211 · exact
EPA reports by year
- 2023
- US production Confidential · Imports Confidential
- 2019
- US production Confidential · Imports Confidential
Source Countries
Country of origin for US imports, from Census customs data (2024).
TW 27%TaiwanDE 23%GermanyCN 14%ChinaKR 13%South KoreaIN 10%India
- Canada
- Netherlands
EPA-registered manufacturers (4)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Basf Se · DE Germany
Ashland
Basf
Lyondell Chemical
Domestic parents -- activity not disclosed (7)
EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.
Albemarle
Cellmark Basic Materials
Emco Chemical Distributors
Ineos Solvents Sales Us
Superior Industrial Solutions
Show all 7
The Lycra
Weylchem Us
EPA-registered importers (24)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Basf Se · DE Germany
Brenntag · DE Germany
Kh Chemicals International B V · NL Netherlands
Novasol North America · CA Canada
Allchem Industries Holding
Show all 24
American River Brokerage
Bedoukian Research
Brenntag Global Marketing
Colonial Group
Exxonmobil Product Solutions, A Div Of Exxon Mobil
Frp Services & Co. (America)
Geocycle
Greenchem Industries
Gulf Coast Growth Ventures
Honeywell International (123312)
Ideal Chemical & Supply
Ips
Kh Chemicals Na
M.A.Global Resources
Systech Environmental
Tedia
The Chemical
Thermo Fisher Scientific
Transchem
Why It Matters
Sectors
HealthAgricultureEnergyConstructionMetals & MiningPlastics & RubberConsumer ProductsPaints & CoatingsPaper & PrintingCore Chemicals
Downstream UsesNot recorded
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No FDA shortage records
Industrial Uses
Used in 16 sectors as 10 functional roles.
- •Monomers in All Other Basic Organic Chemical Manufacturing (100%)Processing as a reactant
- •Solvent in All Other Basic Organic Chemical Manufacturing (80%)Processing—incorporation into formulation, mixture, or reaction product
- •Intermediate in Paint and Coating Manufacturing (1%)Processing as a reactant
- •Intermediate in Wholesale and Retail Trade (72%)Processing—repackaging
- •Laboratory chemicals in Wholesale and Retail Trade (7%)Processing—repackaging
- •Intermediate in Pharmaceutical and Medicine Manufacturing (14%)Processing as a reactant
- •Intermediate in Miscellaneous Manufacturing (2%)Processing as a reactant
- •Intermediate in Rubber Product Manufacturing (4%)Processing as a reactant
- •Intermediate in All Other Basic Organic Chemical ManufacturingProcessing as a reactant
- •Fuel agents in All Other Basic Organic Chemical ManufacturingProcessing—repackaging
- •Solvent in All Other Chemical Product and Preparation Manufacturing (100%)Processing—repackaging
- •Solvent in Miscellaneous ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
- •Catalyst in Plastics Material and Resin Manufacturing (100%)Processing as a reactant
- •Solvent in Pharmaceutical and Medicine Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Catalyst in Petrochemical Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Solvent in Wholesale and Retail TradeProcessing—repackaging
- •Tanning agents not otherwise specified in All Other Basic Organic Chemical ManufacturingUse—non-incorporative activities
- •Intermediate in Plastics Material and Resin ManufacturingProcessing as a reactant
- •Solvent in Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing (90%)Processing—incorporation into formulation, mixture, or reaction product
- •Fuel in Non-metallic Mineral Product Manufacturing (includes clay, glass, cement, concrete, lime, gypsum, and other non-metallic mineral product manufacturing)Processing—repackaging
- •Laboratory chemicals in All Other Basic Organic Chemical ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
- •Laboratory chemicals in ServicesNot Known or Reasonably Ascertainable
- •Intermediate in All Other Chemical Product and Preparation Manufacturing (100%)Processing as a reactant
- •Solvent in Adhesive ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
- •Solvent in Construction (10%)Processing—incorporation into formulation, mixture, or reaction product
- •Solvent in Paint and Coating Manufacturing (10%)Processing—incorporation into formulation, mixture, or reaction product
- •Fragrance in Industrial Gas Manufacturing (5%)Processing—incorporation into formulation, mixture, or reaction product
- •Solvent in Printing Ink Manufacturing (20%)Processing—incorporation into formulation, mixture, or reaction product
- •Anti-adhesive/cohesive in Paint and Coating Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
Vendor Pricing
$0.01/gSigma-Aldrich (Rush Stock)
CountryGermany
Pack$1876.31 / 175 kg
Purity99.9%
Vendors4 available
Prices reflect listed pack sizes. Small research packs run far above bulk rates.
3 more vendors
| Vendor | Country Supplier country. Where available, shows shipping origin. When the supplier ships from a different country than where they are registered, both are shown. Most suppliers show registration country only. | $/g | Pack | Purity |
|---|---|---|---|---|
| Sigma-Aldrich | Germany | $0.01 | 175 kg | 99.9% |
| Apollo Scientific UK | United Kingdom | $0.39 | 100 g | 99% |
| Labotest KG | Germany | $217.80 | 5000 mg | 90% |
Chemical Identity
CAS109-99-9
PubChem CID8028
DTXSIDDTXSID1021328
FormulaC4H8O
Mol. Weight72.11 g/mol
SMILESC1CCOC1
Data Sources
- EPA CompTox (DSSTox) · DTXSID1021328Retrieved 2026-04-06
- PubChem · compound 8028Retrieved 2026-04-06
- EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
- EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
Tetrahydrofuran (CAS 109-99-9) https://chemicalindependence.com/chemical/109-99-9/ EPA CompTox (DSSTox): DTXSID1021328. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID1021328 PubChem: 8028. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/8028 EPA Chemical Data Reporting: 109-99-9. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 109-99-9. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 293211 for CAS 109-99-9. Reporting year: 2024. https://usatrade.census.gov/