Isopropyl acetate

CAS 108-21-4

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$123M

Top sourceIndia 31%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 291539 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 291539, which covers 252 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 31%IndiaCN 18%ChinaDE 13%GermanyMX 8%MexicoGB 7%United Kingdom

Indonesia
Costa Rica
South Korea
Netherlands
Canada
Paraguay
Madagascar
South Africa
Vietnam
Slovakia
Hong Kong
Israel
Singapore
Argentina
Ukraine

EPA-registered manufacturers (2)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Dow Chemical

Solvchem

Domestic parents -- activity not disclosed (2)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Cellmark Basic Materials

Eastman Chemical

EPA-registered importers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Systech Environmental

Why It Matters

Sectors

HealthAgricultureConstructionPlastics & RubberTextilesConsumer ProductsPaints & CoatingsPaper & PrintingCore Chemicals

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 11 sectors as 9 functional roles.

•Solvent in All Other Chemical Product and Preparation ManufacturingProcessing—repackaging
•Solvent in Pharmaceutical and Medicine Manufacturing (1%)Use—non-incorporative activities
•Intermediate in All Other Basic Organic Chemical Manufacturing (100%)Processing—repackaging
•Solvent in Paint and Coating Manufacturing (1%)Processing—incorporation into formulation, mixture, or reaction product
•Fuel in Non-metallic Mineral Product Manufacturing (includes clay, glass, cement, concrete, lime, gypsum, and other non-metallic mineral product manufacturing)Processing—repackaging
•Solvent in Not Known or Reasonably Ascertainable (34%)Not Known or Reasonably Ascertainable
•Laboratory chemicals in Not Known or Reasonably Ascertainable (33%)Not Known or Reasonably Ascertainable
•Fragrance in Not Known or Reasonably Ascertainable (33%)Not Known or Reasonably Ascertainable
•Pigment in Synthetic Dye and Pigment Manufacturing (50%)Processing—incorporation into formulation, mixture, or reaction product
•Pigment in Printing Ink Manufacturing (50%)Processing—incorporation into formulation, mixture, or reaction product
•Surfactant (surface active agent) in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (5%)Processing—incorporation into formulation, mixture, or reaction product
•Intermediate in Pharmaceutical and Medicine Manufacturing (5%)Processing—incorporation into formulation, mixture, or reaction product
•Solvent in Plastics Material and Resin Manufacturing (30%)Processing—incorporation into formulation, mixture, or reaction product
•Plasticizer in Plastics Material and Resin Manufacturing (10%)Processing—incorporation into formulation, mixture, or reaction product
•Stabilizing agent in Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing (10%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.03/gSigma-Aldrich (Rush Stock)

CountryGermany

Pack$650.91 / 20 kg

Purity99%

Vendors7 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

6 more vendors

Vendor	Country	$/g	Pack	Purity
Sigma-Aldrich	Germany	$0.03	20 kg	99%
Combi-Blocks, Inc.	United States	$0.25	1 kg	98%
AstaTech, Inc	United States	$0.31	250 g	99%
A2B Chem LLC	United States	$0.45	1 kg	99%
AA BLOCKS	United States	$0.47	1 kg	99%
Labotest KG	Germany	$217.80	5000 mg	90%

Chemical Identity

CAS108-21-4

PubChem CID7915

DTXSIDDTXSID2025478

FormulaC5H10O2

Mol. Weight102.13 g/mol

SMILESCC(C)OC(=O)C

Data Sources

EPA CompTox (DSSTox) · DTXSID2025478Retrieved 2026-04-06
PubChem · compound 7915Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Isopropyl acetate (CAS 108-21-4) https://chemicalindependence.com/chemical/108-21-4/ EPA CompTox (DSSTox): DTXSID2025478. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID2025478 PubChem: 7915. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/7915 EPA Chemical Data Reporting: 108-21-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 108-21-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 291539 for CAS 108-21-4. Reporting year: 2024. https://usatrade.census.gov/