2,5-Piperazinedione

Drug ingredient

CAS 106-57-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

US productionNot reported

Import value, 2024$907M

Top sourceIreland 47%

This chemical is listed as active in US commerce, but no company reported it to EPA’s survey for 2019 or 2023. Sites may have made or imported less than the threshold amount, or none.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293379 · basket

These shares come from HS customs code 293379, which covers 105 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IE 47%IrelandBE 19%BelgiumSG 11%SingaporeIT 4%ItalyCH 4%Switzerland

Brazil
Canada
Taiwan
Ukraine
Portugal
Netherlands
South Korea
Israel
Czech Republic
Spain
Finland
Hungary
Malaysia
Australia
Austria
Slovenia

1 FDA-registered drug labeler

Deseret Biologicals, Inc.

Why It Matters

Sectors

Health

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Aspartame/MSG Detox

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$0.54/gA2B Chem LLC

CountryUnited States

Pack$54.00 / 100 g

Purity97%

Vendors29 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

28 more vendors

Vendor	Country	$/g	Pack	Purity
AA BLOCKS	United States	$0.61	100 g	95%
Combi-Blocks, Inc.	United States	$0.64	500 g	98%
Aaron Chemicals LLC	Hong Kong	$0.70	100 g	98%
Chemscene	United States	$0.72	500 g	—
BLD Pharmatech Co., Limited	United States	$0.76	500 g	95%
BLD Pharmatech GmbH	Germany	$0.76	500 g	95%
BLD Pharmatech Ltd.	China	$0.76	500 g	95%
Ambeed, Inc.	United States	$0.76	500 g	95%
Angene Chemical	China → Hong Kong	$0.77	100 g	98%
MedChemExpress MCE	Sweden	$0.90	500 g	—
Fluorochem EU	Germany	$0.93	100 g	95%
Fluorochem UK	United Kingdom	$0.94	100 g	95%
Synthonix	United States	$1.00	100 g	95%
AK Scientific, Inc.	United States	$1.28	100 g	98%
AstaTech (2 weeks)	United States	$1.60	25 g	95%
Sigma-Aldrich (Rush Stock)	Germany	$2.25	1 kg	—
Sigma-Aldrich	Germany	$2.25	1 kg	—
Angene International Limited	United States	$2.32	100 g	98%
TargetMol Chemicals	China → United States	$32.50	2 g	—
Interbioscreen	Hong Kong	$34.00	10 g	95%
Specs	Netherlands	$181.26	5 g	90%
Key Organics Ltd.	United Kingdom	$2740.00	50 mg	95%
Princeton BioMolecular Research (SC)	United States	$2900.00	100 mg	90%
Vitas M Chemical Limited	Hong Kong	$3170.00	100 mg	90%
Angene	China → Hong Kong	$4266.67	30 mg	98%
Life Chemicals Inc.	Ukraine → Canada	$7266.67	15 mg	90%
ChemDiv, Inc.	United States	$35000.00	2 mg	90%
TimTec, LLC	United States	$58000.00	5 mg	90%

Chemical Identity

CAS106-57-0

PubChem CID7817

DTXSIDDTXSID8059342

FormulaC4H6N2O2

Mol. Weight114.1 g/mol

SMILESC1C(=O)NCC(=O)N1

Data Sources

PubChem · compound 7817Retrieved 2026-04-07
EPA TSCA InventoryRetrieved 2026-04-24
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

← Back to Dashboard ← Back to Health

Brief citations

2,5-Piperazinedione (CAS 106-57-0) https://chemicalindependence.com/chemical/106-57-0/ PubChem: 7817. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/7817 EPA TSCA Inventory: CAS 106-57-0. Retrieved 2026-04-24. https://www.epa.gov/tsca-inventory FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293379 for CAS 106-57-0. Reporting year: 2024. https://usatrade.census.gov/