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Tacrolimus

Drug ingredient

CAS 104987-11-3

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 104987-11-3
US productionNot reported
Import value, 2024$6.4B
Top sourceSingapore 36%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293499 · basket

These shares come from HS customs code 293499, which covers 575 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries
SG 36%SingaporeIE 23%IrelandCN 11%ChinaCH 6%SwitzerlandIN 5%India
57 FDA-registered drug labelers
A-S Medication Solutions
Accord Healthcare Inc.
Ajenat Pharmaceuticals LLC
American Health Packaging
Amneal Pharmaceuticals NY LLC
Aphena Pharma Solutions - Tennessee, LLC
Ascend Laboratories, LLC
Astellas Pharma Inc.
Astellas Pharma US, Inc.
AX Pharmaceutical Corp
Biocon Limited
Biocon Pharma Inc.
BPI Labs LLC
Bryant Ranch Prepack
Cardinal Health 107, LLC
Chengdu Suncadia Medicine Co., Ltd.
Chunghwa Chemical Synthesis & Biotech. Ltd
CKD Bio Corporation
CMIC CMO CO., LTD.
CONCORD BIOTECH LIMITED
Curia Italy S.r.l.
Darmerica LLC
Direct_Rx
Dr. Reddy's Laboratories Limited
E. Fougera & Co. a division of Fougera Pharmaceuticals, LLC
Encube Ethicals, Inc.
Fishfa Biogenics
Glenmark Pharmaceuticals Inc., USA
Golden State Medical Supply, Inc.
Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd
Hisun Pharmaceutical (Hangzhou) Co., Ltd.
Joyang Laboratories
Jubilant Cadista Pharmaceuticals Inc.
LETCO MEDICAL, LLC
Major Pharmaceuticals
Medisca Inc.
Mylan Pharmaceuticals Inc.
MylanInstitutional Inc.
Nexus Pharmaceuticals, LLC
North China Pharmaceutical Huasheng Co. Ltd.
NORTHSTAR RX LLC
Novartis Pharmaceuticals Corporation
Padagis Israel Pharmaceuticals Ltd
Panacea Biotec Limited
Professional Compounding Centers of America
Proficient Rx LP
Quallent Pharmaceuticals Health LLC
Rottendorf Pharma GmbH
Safecor Health LLC
Sandoz Inc.
Stellon Biotech Inc.
Strides Pharma Science Limited
Suresource Pharma LLC
TAPI Czech Industries s.r.o.
Teva Czech Industries s.r.o
Veloxis Pharmaceuticals, Inc
Wuxi Fortune Pharmaceutical Co.,Ltd.

Why It Matters

Sectors
Health
Downstream Uses

Appears in 4 drug and cosmetic product listings (FDA).

  • •Tacrolimus
  • •Astagraf XL
  • •Prograf
  • •Envarsus XR
FDA Shortage Status
No FDA shortage records

Chemical Identity

CAS104987-11-3
PubChem CID445643
DTXSIDDTXSID5046354
FormulaC44H69NO12
Mol. Weight804 g/mol
SMILESCC1CC(C2C(CC(C(O2)(C(=O)C(=O)N3CCCCC3C(=O)OC(C(C(CC(=O)C(C=C(C1)C)CC=C)O)C)C(=CC4CCC(C(C4)OC)O)C)O)C)OC)OC

Data Sources

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Brief citations

Tacrolimus (CAS 104987-11-3) https://chemicalindependence.com/chemical/104987-11-3/ PubChem: 445643. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/445643 FDA National Drug Code directory: CAS 104987-11-3. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293499 for CAS 104987-11-3. Reporting year: 2024. https://usatrade.census.gov/