1,2-Diphenoxyethane

CAS 104-66-5

Companies reported imports and no US production of this chemical to EPA for 2019.

US productionZero

Import value, 2024$59M

Import volume88.3K lb

Import dependency100%

Top sourceChina 51%

Production is reported production, not a complete census of factories. Production reporting year: 2019. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

1,2-Diphenoxyethane · US import value by year

2013: $68M · Peak 2022: $85M · 2024: $59M · 2025: $33M

Where It Comes From

Customs basis: HS 290930 · basket

EPA reports by year

2023: US production Not published · Imports Not published
2019: US production Zero · Imports 88.3K lb

These shares come from HS customs code 290930, which covers 119 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 51%ChinaIN 23%IndiaIT 12%ItalyJP 9%JapanCA 2%Canada

Spain
Israel
Netherlands
Taiwan
Germany
Ireland
Switzerland
Ukraine
Mexico
United Kingdom
Australia

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Chemdesign Products

EPA-registered importers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Marubeni America

Why It Matters

Sectors

Paper & Printing

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Pigment in Printing and Related Support Activities (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.16/gAaron Chemicals LLC

CountryHong Kong

Pack$78.00 / 500 g

Purity99%

Vendors20 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

19 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$0.17	500 g	99%
A2B Chem LLC	United States	$0.23	500 g	98%
BLD Pharmatech GmbH	Germany	$0.29	500 g	98%
BLD Pharmatech Ltd.	China	$0.29	500 g	98%
AA BLOCKS	United States	$0.30	500 g	99%
Combi-Blocks, Inc.	United States	$0.30	500 g	98%
BLD Pharmatech Co., Limited	United States	$0.31	500 g	98%
Ambeed, Inc.	United States	$0.31	500 g	98%
Synthonix	United States	$0.60	100 g	95%
AK Scientific Specialized	United States	$0.61	100 g	98%
AK Scientific, Inc.	United States	$0.82	100 g	99%
Angene International Limited	United States	$1.29	100 g	98%
Sigma-Aldrich (Rush Stock)	Germany	$5.84	5 g	99%
Sigma-Aldrich	Germany	$5.84	5 g	99%
AstaTech (2 weeks)	United States	$7.81	100 g	95%
TargetMol Chemicals	China → United States	$30.00	1 g	99.84%
Labotest KG	Germany	$453.00	1000 mg	90%
Angene	China → Hong Kong	$4266.67	30 mg	99%
TimTec, LLC	United States	$9333.33	30 mg	99%

Chemical Identity

CAS104-66-5

PubChem CID7713

DTXSIDDTXSID5026706

FormulaC14H14O2

Mol. Weight214.26 g/mol

SMILESC1=CC=C(C=C1)OCCOC2=CC=CC=C2

Data Sources

EPA CompTox (DSSTox) · DTXSID5026706Retrieved 2026-04-06
PubChem · compound 7713Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2019 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

1,2-Diphenoxyethane (CAS 104-66-5) https://chemicalindependence.com/chemical/104-66-5/ EPA CompTox (DSSTox): DTXSID5026706. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID5026706 PubChem: 7713. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/7713 EPA Chemical Data Reporting: 104-66-5. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 104-66-5. Reporting year: 2019. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 290930 for CAS 104-66-5. Reporting year: 2024. https://usatrade.census.gov/