1,4-Diisocyanatobenzene

CAS 104-49-4

EPA’s 2023 records show zero U.S. production of this chemical.

US productionZero

Import value, 2024$171M

Import volumeCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Top sourceHungary 35%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292910 · basket

EPA reports by year

2023: US production Zero · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 292910, which covers 57 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

HU 35%HungaryDE 20%GermanyIT 15%ItalyCN 8%ChinaES 7%Spain

Mexico
India
Switzerland
Panama
United Kingdom
Egypt
Ukraine
Poland
Finland
Malaysia
Slovakia
Austria

EPA-registered importers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Lanxess

Why It Matters

Sectors

Paper & Printing

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Intermediate in Paper Manufacturing (100%)Processing as a reactant

Vendor Pricing

$0.23/gAaron Chemicals LLC

CountryHong Kong

Pack$116.00 / 500 g

PurityNot recorded

Vendors11 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

10 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$0.25	500 g	—
A2B Chem LLC	United States	$0.40	500 g	98%
AA BLOCKS	United States	$0.52	500 g	98%
Combi-Blocks, Inc.	United States	$0.90	500 g	98%
AK Scientific, Inc.	United States	$1.19	500 g	98%
Sigma-Aldrich (Rush Stock)	Germany	$1.40	100 g	—
Sigma-Aldrich	Germany	$1.40	100 g	—
Angene International Limited	United States	$4.32	25 g	98%
Labotest KG	Germany	$217.80	5000 mg	90%
Angene	China → Hong Kong	$4266.67	30 mg	—

Chemical Identity

CAS104-49-4

PubChem CID61009

DTXSIDDTXSID3025883

FormulaC8H4N2O2

Mol. Weight160.13 g/mol

SMILESC1=CC(=CC=C1N=C=O)N=C=O

Data Sources

EPA CompTox (DSSTox) · DTXSID3025883Retrieved 2026-04-06
PubChem · compound 61009Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

1,4-Diisocyanatobenzene (CAS 104-49-4) https://chemicalindependence.com/chemical/104-49-4/ EPA CompTox (DSSTox): DTXSID3025883. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID3025883 PubChem: 61009. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/61009 EPA Chemical Data Reporting: 104-49-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 104-49-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 292910 for CAS 104-49-4. Reporting year: 2024. https://usatrade.census.gov/