Maprotiline hydrochloride

Drug ingredient

CAS 10347-81-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 10347-81-6 — 1 HCl

US productionNot reported

Import value, 2024$41M

Top sourceIndia 37%

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Production is reported production, not a complete census of factories. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292149 · basket

These shares come from HS customs code 292149, which covers 80 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

IN 37%IndiaCN 25%ChinaDE 14%GermanyMX 9%MexicoGB 4%United Kingdom

Israel
Ireland
Czech Republic
Singapore
Slovakia
Lithuania
Belgium
Australia

1 FDA-registered drug labeler

Olon SpA

Why It Matters

Sectors

Health

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Vendor Pricing

$8.37/gAaron Chemicals LLC

CountryHong Kong

Pack$837.00 / 100 g

Purity98%

Vendors18 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

17 more vendors

Vendor	Country	$/g	Pack	Purity
Angene Chemical	China → Hong Kong	$8.95	100 g	98%
A2B Chem LLC	United States	$19.28	25 g	99%
AA BLOCKS	United States	$25.24	25 g	99%
Interbioscreen	Hong Kong	$34.00	10 g	95%
Sigma-Aldrich (Rush Stock)	Germany	$80.34	5 g	99%
Sigma-Aldrich	Germany	$80.34	5 g	99%
Angene International Limited	United States	$120.00	5 g	98%
MedKoo Biosciences, Inc	United States	$290.00	5 g	98%
CliniSciences GmbH	Switzerland	$322.50	100 mg	99%
MedChemExpress MCE	Sweden	$329.12	500 mg	99.91%
Molnova	China	$340.00	200 mg	99%
TargetMol Chemicals	China → United States	$375.00	200 mg	99.99%
Cayman Europe	Estonia	$730.66	500 mg	98%
Apexbio Technology LLC	United States	$1000.00	50 mg	98.45%
Princeton BioMolecular Research (SC)	United States	$2900.00	100 mg	90%
Vitas M Chemical Limited	Hong Kong	$3170.00	100 mg	90%
Angene	China → Hong Kong	$4266.67	30 mg	98%

Chemical Identity

CAS10347-81-6

PubChem CID71478

DTXSIDDTXSID2044507

FormulaC20H24ClN

Mol. Weight313.9 g/mol

SMILESCNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24.Cl

Data Sources

PubChem · compound 71478Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Maprotiline hydrochloride (CAS 10347-81-6) https://chemicalindependence.com/chemical/10347-81-6/ PubChem: 71478. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/71478 FDA National Drug Code directory: CAS 10347-81-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292149 for CAS 10347-81-6. Reporting year: 2024. https://usatrade.census.gov/