nickel sulfate hexahydrate

Drug ingredient

CAS 10101-97-0

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 10101-97-0 — 6 H₂O · 1 Ni²⁺

US production80.4K lb

Import value, 2024$16M

Import volume335.1K lb

Import dependency81%

Top sourceBelgium 50%

Production is reported production, not a complete census of factories. Production reporting year: 2023.

Where It Comes From

Customs basis: HS 283324 · exact

EPA reports by year

2023: US production 80.4K lb · Imports 335.1K lb

Source Countries

Country of origin for US imports, from Census customs data (2024).

BE 50%BelgiumAU 29%AustraliaFI 9%FinlandZA 9%South AfricaTW 1%Taiwan

Norway
Germany

EPA-registered manufacturers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Macdermid

5 FDA-registered drug labelers

BioActive Nutritional, Inc.

Hahnemann Laboratories, INC.

OHM PHARMA INC.

PLYMOUTH HEALTHCARE PRODUCTS LLC

Professional Complementary Health Formulas

Why It Matters

Sectors

HealthCore Chemicals

Downstream Uses

Appears in 8 drug and cosmetic product listings (FDA).

•Niccolum Sulphuricum
•Vitalizer
•Eczema
•Metex 6013
•Eczema Relief
•Acne Relief
•ACNE
•Psoriasis

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 1 sector as 3 functional roles.

•Plating agent in All Other Chemical Product and Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
•Etching agent in All Other Chemical Product and Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
•Chelating agent in All Other Chemical Product and Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS10101-97-0

PubChem CID5284429

DTXSIDDTXSID7020928

FormulaH12NiO10S

Mol. Weight262.85 g/mol

SMILESO.O.O.O.O.O.[O-]S(=O)(=O)[O-].[Ni+2]

Data Sources

PubChem · compound 5284429Retrieved 2026-04-07
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

nickel sulfate hexahydrate (CAS 10101-97-0) https://chemicalindependence.com/chemical/10101-97-0/ PubChem: 5284429. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/5284429 EPA Chemical Data Reporting: 10101-97-0. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 283324 for CAS 10101-97-0. Reporting year: 2024. https://usatrade.census.gov/