Calcium sulfate dihydrate

Drug ingredient

CAS 10101-41-4

This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.

Molecular structure of 10101-41-4 — 2 H₂O · 1 Ca²⁺

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$179M

Top sourceMexico 46%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 283329 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential

These shares come from HS customs code 283329, which covers 36 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

MX 46%MexicoCN 19%ChinaCA 11%CanadaIN 9%IndiaFI 4%Finland

Italy
South Africa
Colombia
United Kingdom
Peru
Czech Republic
Taiwan
Hong Kong
Sweden
Belgium
Singapore
Netherlands
Hungary
Switzerland

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Target

EPA-registered importers (3)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Sojitz · JP Japan

Sojitz Corporation Of America

Spectrum Laboratory Products

1 FDA-registered drug labeler

Martin & Pleasance Pty Ltd

Why It Matters

Sectors

HealthAgricultureCore Chemicals

Downstream Uses

Appears in 3 drug and cosmetic product listings (FDA).

•Schuessler Tissue Salts Comb D Skin Disorders
•Schuessler Tissue Salts Calc Sulph Blood Cleanser 3
•Schuessler Tissue Salts Comb 12 General Tonic

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Soil amendments (fertilizers) in Agriculture, Forestry, Fishing and Hunting (100%)Processing—repackaging

Chemical Identity

CAS10101-41-4

PubChem CID24928

DTXSIDDTXSID7047514

FormulaCaH4O6S

Mol. Weight172.17 g/mol

SMILESO.O.[O-]S(=O)(=O)[O-].[Ca+2]

Data Sources

PubChem · compound 24928Retrieved 2026-04-07
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Calcium sulfate dihydrate (CAS 10101-41-4) https://chemicalindependence.com/chemical/10101-41-4/ PubChem: 24928. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/24928 EPA Chemical Data Reporting: 10101-41-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 283329 for CAS 10101-41-4. Reporting year: 2024. https://usatrade.census.gov/