4,4'-Diphenylmethane diisocyanate
CAS 101-68-8
U.S. production volumes are classified as confidential business information.
US productionCBI
Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.
Import value, 2024$171M
Top sourceHungary 35%
At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.
Why supply is unknownProduction is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 292910 · basket
EPA reports by year
- 2023
- US production Confidential · Imports Confidential
- 2019
- US production Confidential · Imports Confidential
These shares come from HS customs code 292910, which covers 57 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
HU 35%HungaryDE 20%GermanyIT 15%ItalyCN 8%ChinaES 7%Spain
- Mexico
- India
- Switzerland
- Panama
- United Kingdom
- Egypt
- Ukraine
- Poland
- Finland
- Malaysia
- Slovakia
- Austria
EPA-registered manufacturers (6)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Basf Se · DE Germany
Basf
Covestro
Huntsman
Inland Coatings
Show all 6
Proviron
Domestic parents -- activity not disclosed (5)
EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.
Azelis Americas Case
Bridgestone Sporting Goods Mfg Usa
Polyventive
Third Coast Packaging
Wego Chemical Group
EPA-registered importers (23)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Azelis S A · LU Luxembourg
Basf Se · DE Germany
Era Polymers International Usa Pty · AU Australia
Mercedes-Benz Ag · DE Germany
Posco Holdings · KR South Korea
Show all 23
Sika Ag · CH Switzerland
3M
Azelis Us Holdings
Blachford
Dow Chemical
Era Polymers
Henkel
Lanxess
Mercedes Benz U.S
Mitsui Chemicals America
Pacific Manufacturing Ohio
Posco International America
Sika
The Sherwin Williams
Tri-Iso
Uzin Utz North America
Vitesco Technologies Usa
Wanhua Chemical America
Why It Matters
Sectors
EnergyElectronicsTransportationConstructionMetals & MiningPlastics & RubberConsumer ProductsPaints & CoatingsPaper & PrintingCore Chemicals
Downstream UsesNot recorded
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No FDA shortage records
Industrial Uses
Used in 17 sectors as 9 functional roles.
- •Adhesion/cohesion promoter in Wood Product Manufacturing (100%)Processing—incorporation into article
- •Monomers in Adhesive Manufacturing (100%)Processing as a reactant
- •Adhesion/cohesion promoter in Electrical Equipment, Appliance, and Component Manufacturing (20%)Processing—incorporation into article
- •Adhesion/cohesion promoter in Computer and Electronic Product Manufacturing (40%)Processing—incorporation into article
- •Adhesion/cohesion promoter in Machinery Manufacturing (40%)Processing—incorporation into article
- •Hardener in Transportation Equipment Manufacturing (100%)Processing—incorporation into article
- •Hardener in Machinery Manufacturing (35%)Processing—incorporation into article
- •Hardener in All Other Chemical Product and Preparation Manufacturing (15%)Processing—incorporation into formulation, mixture, or reaction product
- •Hardener in Plastics Material and Resin Manufacturing (10%)Processing—incorporation into formulation, mixture, or reaction product
- •Intermediate in All Other Basic Organic Chemical Manufacturing (100%)Processing—repackaging
- •Elasticizer in Wholesale and Retail Trade (100%)Not Known or Reasonably Ascertainable
- •Intermediate in Plastics Material and Resin Manufacturing (20%)Processing as a reactant
- •Monomers in Plastics Material and Resin Manufacturing (80%)Processing as a reactant
- •Monomers in Furniture and Related Product ManufacturingProcessing as a reactant
- •Monomers in Wood Product ManufacturingProcessing as a reactant
- •Sealant (barrier) in Paint and Coating Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Surface modifier in Paint and Coating Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Monomers in Transportation Equipment Manufacturing (0%)Processing as a reactant
- •Monomers in Computer and Electronic Product Manufacturing (0%)Processing as a reactant
- •Monomers in Miscellaneous Manufacturing (80%)Processing as a reactant
- •Hardener in Paint and Coating Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Monomers in Synthetic Rubber Manufacturing (100%)Processing as a reactant
- •Binder in Plastics Material and Resin Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Intermediate in Plastics Product Manufacturing (1%)Processing—incorporation into formulation, mixture, or reaction product
- •Adhesion/cohesion promoter in Transportation Equipment Manufacturing (100%)Processing—incorporation into article
- •Binder in Paint and Coating ManufacturingProcessing as a reactant
- •Binder in Adhesive ManufacturingProcessing as a reactant
- •Intermediate in ConstructionProcessing as a reactant
- •Monomers in ConstructionProcessing as a reactant
- •Monomers in Other (0%)Processing—incorporation into formulation, mixture, or reaction product
- •Monomers in Plastics Product Manufacturing (0%)Processing as a reactant
- •Polymerization promoter in All Other Chemical Product and Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
Vendor Pricing
$0.15/gALFA AESAR
CountryGermany
Pack$74.28 / 500 g
Purity98%
Vendors6 available
Prices reflect listed pack sizes. Small research packs run far above bulk rates.
5 more vendors
| Vendor | Country Supplier country. Where available, shows shipping origin. When the supplier ships from a different country than where they are registered, both are shown. Most suppliers show registration country only. | $/g | Pack | Purity |
|---|---|---|---|---|
| Sigma-Aldrich (Rush Stock) | Germany | $0.15 | 5 kg | 98% |
| Sigma-Aldrich | Germany | $0.15 | 5 kg | 98% |
| Combi-Blocks, Inc. | United States | $0.30 | 500 g | 97% |
| Fluorochem UK | United Kingdom | $3.15 | 10 g | 97% |
| Labotest KG | Germany | $217.80 | 5000 mg | 90% |
Chemical Identity
CAS101-68-8
PubChem CID7570
DTXSIDDTXSID7025180
FormulaC15H10N2O2
Mol. Weight250.25 g/mol
SMILESC1=CC(=CC=C1CC2=CC=C(C=C2)N=C=O)N=C=O
Data Sources
- EPA CompTox (DSSTox) · DTXSID7025180Retrieved 2026-04-06
- PubChem · compound 7570Retrieved 2026-04-06
- EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
- EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
4,4'-Diphenylmethane diisocyanate (CAS 101-68-8) https://chemicalindependence.com/chemical/101-68-8/ EPA CompTox (DSSTox): DTXSID7025180. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID7025180 PubChem: 7570. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/7570 EPA Chemical Data Reporting: 101-68-8. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 101-68-8. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 292910 for CAS 101-68-8. Reporting year: 2024. https://usatrade.census.gov/