4,4'-Methylenebis(2-chloroaniline)

CAS 101-14-4

EPA’s 2023 records show zero U.S. production of this chemical.

US productionZero

Import value, 2024$84M

Import volumeCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Top sourceJapan 31%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 292159 · basket

EPA reports by year

2023: US production Zero · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 292159, which covers 51 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

JP 31%JapanIN 26%IndiaCN 21%ChinaCH 13%SwitzerlandBE 4%Belgium

United Kingdom
South Korea
Canada
Italy
Ukraine
Netherlands

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

K-I Chemical U.S.A

EPA-registered importers (5)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Era Polymers International Usa Pty · AU Australia

Dupont Specialty Products Usa

Era Polymers

Lanxess

Tri-Iso

Why It Matters

Sectors

TransportationMetals & MiningPlastics & Rubber

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 3 sectors as 2 functional roles.

•Hardener in Plastics Material and Resin ManufacturingProcessing as a reactant
•Hardener in Mining (except Oil and Gas) and support activities (50%)Processing as a reactant
•Hardener in Transportation Equipment Manufacturing (50%)Processing as a reactant
•Chemical reaction regulator in Plastics Material and Resin Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.23/gAA BLOCKS

CountryUnited States

Pack$113.00 / 500 g

PurityNot recorded

Vendors10 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

9 more vendors

Vendor	Country	$/g	Pack	Purity
A2B Chem LLC	United States	$0.25	500 g	—
Sigma-Aldrich (Rush Stock)	Germany	$0.50	1 kg	85%
Sigma-Aldrich	Germany	$0.50	1 kg	85%
AK Scientific, Inc.	United States	$0.96	100 g	85%
MedKoo Biosciences, Inc	United States	$4.50	100 g	98%
ChemBridge Corporation	Kazakhstan	$25.00	1 g	95%
Labotest KG	Germany	$453.00	1000 mg	90%
Princeton BioMolecular Research (SC)	United States	$8000.00	15 mg	90%
Vitas M Chemical Limited	Hong Kong	$9000.00	10 mg	90%

Chemical Identity

CAS101-14-4

PubChem CID7543

DTXSIDDTXSID5020865

FormulaC13H12Cl2N2

Mol. Weight267.15 g/mol

SMILESC1=CC(=C(C=C1CC2=CC(=C(C=C2)N)Cl)Cl)N

Data Sources

EPA CompTox (DSSTox) · DTXSID5020865Retrieved 2026-04-06
PubChem · compound 7543Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

4,4'-Methylenebis(2-chloroaniline) (CAS 101-14-4) https://chemicalindependence.com/chemical/101-14-4/ EPA CompTox (DSSTox): DTXSID5020865. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020865 PubChem: 7543. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/7543 EPA Chemical Data Reporting: 101-14-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 101-14-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 292159 for CAS 101-14-4. Reporting year: 2024. https://usatrade.census.gov/