Lead metasilicate (PbSiO3)

Drug ingredient

CAS 10099-76-0

Companies reported imports and no US production of this drug ingredient to EPA for 2023.

US productionZero

Import value, 2024$21M

Import volume31.3K lb

Import dependency100%

Top sourceMexico 25%

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Lead metasilicate (PbSiO3) · US import value by year

2013: $18M · Peak 2019: $25M · 2024: $21M · 2025: $16M

Where It Comes From

Customs basis: HS 283990 · basket

EPA reports by year

2023: US production Zero · Imports 31.3K lb
2019: US production Zero · Imports 43.4K lb

These shares come from HS customs code 283990, which covers 20 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

MX 25%MexicoCA 17%CanadaDE 12%GermanyIT 12%ItalyJP 9%Japan

Malaysia
Denmark
Turkey
Switzerland
Poland
Hong Kong
Czech Republic
Finland
Australia
Spain
Austria

EPA-registered importers (2)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Teck Resources · CA Canada

Teck American Incorporated

Why It Matters

Sectors

HealthConstruction

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•Plumbum silicicum 20
•Helleborus comp. A

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Intermediate in Non-metallic Mineral Product Manufacturing (includes clay, glass, cement, concrete, lime, gypsum, and other non-metallic mineral product manufacturing) (100%)Processing—incorporation into formulation, mixture, or reaction product

Chemical Identity

CAS10099-76-0

PubChem CIDNot recorded

DTXSIDDTXSID90893100

FormulaNot recorded

Mol. WeightNot recorded

SMILESNot recorded

Data Sources

EPA CompTox (DSSTox) · DTXSID90893100Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Lead metasilicate (PbSiO3) (CAS 10099-76-0) https://chemicalindependence.com/chemical/10099-76-0/ EPA CompTox (DSSTox): DTXSID90893100. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID90893100 EPA Chemical Data Reporting: 10099-76-0. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 10099-76-0. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 283990 for CAS 10099-76-0. Reporting year: 2024. https://usatrade.census.gov/