Chlorine dioxide

Drug ingredient

CAS 10049-04-4

This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$75M

Top sourceChina 30%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 281129 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 281129, which covers 18 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 30%ChinaAT 23%AustriaPL 9%PolandCA 8%CanadaCZ 8%Czech Republic

Italy
Romania
Malaysia
India
Netherlands
Ukraine
Denmark
Singapore
Switzerland
Morocco
United Kingdom

EPA-registered manufacturers (27)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Karta Halten B V · NL Netherlands

Billerud

Billerud Escanaba

Clearwater Paper

Domtar

Show all 27

Domtar Paper Company, Llc - Ha

Evergreen Packaging

Finch Paper

Global Win Capital

Graphic Packaging International

International Grand Investment

International Grand Investment Corporation (Igic)

International Paper

International Paper - Flint River Mill

Koch Industries

Nd Paper

Nippon Paper Industries Usa

Packaging Corporation Of America

Pixelle Specialty Solutions

Rayonier

Rayonier Performance Fibers

Resolute Fp Us Inc, Coosa Pines Operations

Reynolds Group Holdings

Sappi Cloquet

Sdw Holdings

Sylvamo North America

Westrock

Domestic parents -- activity not disclosed (2)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Capital Recovery Group

New-Indy Jv

1 FDA-registered drug labeler

Pure O2

Why It Matters

Sectors

HealthAgriculturePaper & Printing

Downstream Uses

Appears in 2 drug and cosmetic product listings (FDA).

•PURE O2-S F
•PURE O2 S

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 2 sectors as 3 functional roles.

•Bleaching agent in Paper Manufacturing (100%)Use—non-incorporative activities
•Sealant (barrier) in Paper Manufacturing (100%)Use—non-incorporative activities
•Bleaching agent in Agriculture, Forestry, Fishing and Hunting (100%)Use—non-incorporative activities
•Oxidizing agent in Paper Manufacturing (100%)Use—non-incorporative activities

Chemical Identity

CAS10049-04-4

PubChem CID24870

DTXSIDDTXSID5023958

FormulaClO2

Mol. Weight67.45 g/mol

SMILESO=Cl[O]

Data Sources

EPA CompTox (DSSTox) · DTXSID5023958Retrieved 2026-04-06
PubChem · compound 24870Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Chlorine dioxide (CAS 10049-04-4) https://chemicalindependence.com/chemical/10049-04-4/ EPA CompTox (DSSTox): DTXSID5023958. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID5023958 PubChem: 24870. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/24870 EPA Chemical Data Reporting: 10049-04-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: CAS 10049-04-4. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 281129 for CAS 10049-04-4. Reporting year: 2024. https://usatrade.census.gov/