Calcium chloride
Drug ingredientCAS 10043-52-4
This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.
US productionCBI
Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.
Import value, 2024$66M
Top sourceMexico 41%
At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.
Why supply is unknownProduction is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.
Where It Comes From
Customs basis: HS 282720 · narrow
EPA reports by year
- 2023
- US production Confidential · Imports Confidential
- 2019
- US production Confidential · Imports Confidential
These shares come from HS customs code 282720, which covers 2 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.
Source Countries
Country of origin for US imports, from Census customs data (2024).
MX 41%MexicoCN 31%ChinaCA 10%CanadaCZ 10%Czech RepublicNL 1%Netherlands
- Malaysia
- Japan
- Switzerland
- Finland
- South Korea
- Italy
- Austria
- Algeria
- Poland
- Thailand
EPA-registered manufacturers (4)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Honeywell International (123312)
Martin Marietta Materials
Tetra Technologies
Usal
Domestic parents -- activity not disclosed (7)
EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.
Calfrac Well Services
Halliburton
Multi-Chem Group
Polyventive
Quadra Chemicals
Show all 7
Schlumberger
Teck American Incorporated
EPA-registered importers (14)
Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.
Biobest Group Nv · BE Belgium
Acs Chemical
American International Chemical
Brenntag Lubricants
Catalynt Solutions
Show all 14
Kik International
Plant Products Holdings Usa
Rpm
Target
Univar Solutions Usa
Valudor Products
Wilbur-Ellis Holdings Ii
Willert Home Products
Wintersun International
40 FDA-registered drug labelers
Alcon Laboratories, Inc.
American Regent, Inc.
Amneal Pharmaceuticals LLC
Apex Energetics Inc.
Asclemed USA, Inc.
Avantor Performance Materials International, LLC
B. Braun Medical Inc.
Baxter Healthcare Company
Baxter Healthcare Corporation
Becton Dickinson and Company
Civica, Inc.
Deseret Biologicals, Inc.
Dr. Reddy's Laboratories Inc.
Fresenius Kabi USA, LLC
Fresenius Medical Care de Mexico, S.A. de C.V.
Fresenius Medical Care North America
Fresenius Medical Care Renal Therapies Group, LLC
Hahnemann Laboratories, INC.
Henry Schein, Inc.
HF Acquisition Co LLC, DBA HealthFirst
Hospira, Inc.
ICU Medical Inc.
International Medication Systems, Limited
LETCO MEDICAL, LLC
Lukare Medical, LLC
Macco Organiques, S.R.O.
Medefil, Inc.
Medical Purchasing Solutions, LLC
Merck KGaA
Nutritional Specialties, Inc.
Professional Complementary Health Formulas
Professional Compounding Centers of America
ProPharma Distribution
REMEDYREPACK INC.
Siegfried Hameln GmbH
Somerset Therapeutics, LLC
Spectrum Laboratory Products, Inc.
SQUARE PHARMACEUTICALS PLC.
Vantive US Healthcare LLC
Vitality Works, Inc.
Why It Matters
Sectors
HealthAgricultureFoodEnergyWaterConstructionMetals & MiningConsumer ProductsPaper & PrintingCore Chemicals
Downstream Uses
Appears in 32 drug and cosmetic product listings (FDA).
- •Dianeal Low Calcium with Dextrose
- •Dianeal PD-2 with Dextrose
- •Lactated Ringers
- •Delflex
- •Kabiven
- •Lactated Ringers and Dextrose
- •Extraneal
- •Ringers
Show all 32
- •Calcarea Muriatica
- •Clinimix E
- •Cardioplegic
- •calcium chloride
- •Potassium Chloride in Lactated Ringers and Dextrose
- •Phoxillum BK4/2.5
- •Elliotts B
- •C08 Calcium Metabolism
- •Bone Liquescence
- •Epl-Cell Repair
- •BSS
- •Prismasol BGK4/2.5
- •Bone Stim Liquescence 3005
- •Balanced Salt
- •TPN Electrolytes
- •Prismasol BGK2/3.5
- •Prismasol BGK0/2.5
- •Calcium Chloride Dihydrate
- •Plegisol
- •Dextrose in Lactated Ringers
- •Perikabiven
- •Oratox
- •Cardioplegic Solution
- •Lactated Ringers Irrigation
FDA Shortage Status
Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."
No Shortage
Shortage History
Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.
- to be discontinued
Calcium Chloride Injection
Shortage listed since November 7, 2025
Industrial Uses
Used in 12 sectors as 18 functional roles.
- •Anti-freeze agent in All Other Basic Inorganic Chemical Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Binder in Oil and Gas Drilling, Extraction, and Support activities (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Density modifier in Oil and Gas Drilling, Extraction, and Support activities (10%)Processing—incorporation into formulation, mixture, or reaction product
- •Intermediate in All Other Chemical Product and Preparation Manufacturing (50%)Processing—incorporation into formulation, mixture, or reaction product
- •Opacifer in Paper Manufacturing (9%)Processing—incorporation into formulation, mixture, or reaction product
- •Viscosity modifiers in Construction (6%)Processing—incorporation into formulation, mixture, or reaction product
- •Soil amendments (fertilizers) in Agriculture, Forestry, Fishing and Hunting (4%)Processing—incorporation into formulation, mixture, or reaction product
- •Preservative in Food, beverage, and tobacco product manufacturing (5%)Processing—incorporation into formulation, mixture, or reaction product
- •Surfactant (surface active agent) in Construction (8%)Processing—incorporation into formulation, mixture, or reaction product
- •Solids separation (precipitating) agent, not otherwise specified in Utilities (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Processing aids, specific to petroleum production in Oil and Gas Drilling, Extraction, and Support activities (30%)Processing—incorporation into formulation, mixture, or reaction product
- •Lubricating agent in Wholesale and Retail Trade (0%)Processing—incorporation into formulation, mixture, or reaction product
- •Adsorbent in Wholesale and Retail TradeProcessing—repackaging
- •Stabilizing agent in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
- •Laboratory chemicals in Not Known or Reasonably AscertainableNot Known or Reasonably Ascertainable
- •Flocculating agent in Utilities (97%)Use—non-incorporative activities
- •Dust suppressant in Mining (except Oil and Gas) and support activitiesUse—non-incorporative activities
- •Freeze-thaw additive in All Other Chemical Product and Preparation ManufacturingProcessing—incorporation into formulation, mixture, or reaction product
Chemical Identity
CAS10043-52-4
PubChem CID5284359
DTXSIDDTXSID5020235
FormulaCaCl2
Mol. Weight110.98 g/mol
SMILES[Cl-].[Cl-].[Ca+2]
Data Sources
- EPA CompTox (DSSTox) · DTXSID5020235Retrieved 2026-04-06
- PubChem · compound 5284359Retrieved 2026-04-06
- EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
- FDA Drug ShortagesRetrieved 2026-10-04
- US Census international tradeReporting year: 2024 · Retrieved 2026-10-04
Brief citations
Calcium chloride (CAS 10043-52-4) https://chemicalindependence.com/chemical/10043-52-4/ EPA CompTox (DSSTox): DTXSID5020235. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID5020235 PubChem: 5284359. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/5284359 EPA Chemical Data Reporting: 10043-52-4. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA Drug Shortages: CAS 10043-52-4. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/ US Census international trade: HS 282720 for CAS 10043-52-4. Reporting year: 2024. https://usatrade.census.gov/