Irinotecan hydrochloride

Drug ingredient

CAS 100286-90-6

This chemical is an active pharmaceutical ingredient used in FDA-regulated drugs.

Molecular structure of 100286-90-6 — 1 HCl

US productionNot reported

Top sourceNo public record

This chemical is not on EPA’s Toxic Substances Control Act inventory, the list behind EPA’s production survey.

Why supply is unknown

Where It Comes From

EPA and Census publish no US supply data for this chemical.

28 FDA-registered drug labelers

Actavis Pharma, Inc.

Apotex Corp.

Armas Pharmaceuticals Inc.

BluePoint Laboratories

Emcure Pharmaceuticals Limited

Eugia US LLC

Fermion Oy

Fresenius Kabi USA, LLC

Gland Pharma Limited

Hetero Labs Limited

Hikma Pharmaceuticals USA Inc.

Hospira, Inc.

Hubei Haosun Pharmaceutical Co., Ltd.

Ingenus Pharmaceuticals, LLC

Ipsen Biopharmaceuticals, Inc.

Jiangsu Hengrui Pharmaceuticals Co., Ltd.

Laurus Labs Limited

Northstar Rx LLC

Olon SpA

Pharmacia & Upjohn Company LLC

Qilu Pharmaceutical Co., Ltd.

Sagent Pharmaceuticals

ScinoPharm Taiwan Ltd.

Shandong Anxin Pharmaceutical Co., Ltd.

SHILPA PHARMA LIFESCIENCES LIMITED

Sichuan Xieli Pharmaceutical Co., Ltd.

SUN PHARMACEUTICAL INDUSTRIES, INC.

Xiromed LLC

Why It Matters

Sectors

Health

Downstream Uses

Appears in 6 drug and cosmetic product listings (FDA).

•Irinotecan Hydrochloride
•Camptosar
•Irinotecan Hydrochloride 100 mg/5 mL
•Irinotecan Hydrochloride 40 mg/2 mL
•Irinotecan hydrochloide
•Onivyde

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No Shortage

Shortage History

Rows group FDA shortage filings by drug product. Each manufacturer makes its own FDA shortage filing, so one product can carry several reports at once: Available, Limited Availability, Unavailable or to be discontinued.

to be discontinued
Irinotecan Hydrochloride Injection
Shortage listed since August 4, 2025

See all current drug shortages

Chemical Identity

CAS100286-90-6

PubChem CID74990

DTXSIDDTXSID6045953

FormulaC33H39ClN4O6

Mol. Weight623.1 g/mol

SMILESCCC1=C2CN3C(=CC4=C(C3=O)COC(=O)C4(CC)O)C2=NC5=C1C=C(C=C5)OC(=O)N6CCC(CC6)N7CCCCC7.Cl

Data Sources

PubChem · compound 74990Retrieved 2026-04-07
FDA National Drug Code directoryRetrieved 2026-04-25
FDA Drug ShortagesRetrieved 2026-10-04

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Brief citations

Irinotecan hydrochloride (CAS 100286-90-6) https://chemicalindependence.com/chemical/100286-90-6/ PubChem: 74990. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/74990 FDA National Drug Code directory: CAS 100286-90-6. Retrieved 2026-04-25. https://open.fda.gov/data/ndc/ FDA Drug Shortages: CAS 100286-90-6. Retrieved 2026-10-04. https://www.accessdata.fda.gov/scripts/drugshortages/