Methenamine

Drug ingredient

CAS 100-97-0

This drug ingredient has classified U.S. production volumes. EPA withholds the number as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$309M

Top sourceChina 40%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 293369 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 293369, which covers 192 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 40%ChinaJP 19%JapanIN 15%IndiaES 11%SpainDE 5%Germany

Canada
Austria
United Kingdom
Netherlands
United Arab Emirates
Malaysia
Indonesia
Turkey
Belgium
Ukraine
Hungary
Latvia
Russia
Hong Kong

EPA-registered manufacturers (3)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Ascend Performance Materials

Bakelite Us Hold

Minerals Technologies

Domestic parents -- activity not disclosed (1)

EPA records name a US company for this chemical but do not disclose whether the company made it here or imported it.

Si Group

EPA-registered importers (8)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Sumitomo Bakelite · JP Japan

Akrochem

Continental Tire Holding Us

Flow Polymers

Harwick Standard Distribution

Show all 8

Sumitomo Bakelite North America Holding

Tenneco Brake

Wabtec

24 FDA-registered drug labelers

Allegis Pharmaceuticals, LLC

AmerisourceBergen Drug Corp

AMOL PHARMACEUTICALS PRIVATE LIMITED

Chain Drug Consortium, LLC

Chain Drug Marketing Association

Chattem Chemicals, Inc.

Clarion Brands, LLC

CVS Pharmacy, Inc

DNA Labs, Inc.

DORAL PHARMAMEDICS INC dba A.G. Marin Pharmaceuticals

EDWARDS PHARMACEUTICALS, INC.

GUANGZHOU HANPU PHARMACEUTICAL CO LTD

i-Health, Inc.

Meijer Distribution Inc.

Method Pharmaceuticals

Method Pharmaceuticals, LLC

Mission Pharmacal Company

Reese Pharmaceutical Co

Rising Pharma Holdings, Inc.

Rite Aid

Spectrum Laboratory Products, Inc.

Topco Associates LLC

Viatris Specialty LLC

Walgreen Company

Why It Matters

Sectors

HealthDefenseEnergyTransportationMetals & MiningPlastics & RubberCore Chemicals

Downstream Uses

Appears in 24 drug and cosmetic product listings (FDA).

•Premier Value Antibacterial Plus Urinary Pain Relief
•Cystex Plus
•Uribel TABS
•URO-PAIN Dual Action Antibacterial Protection
•Quality Choice Antibacterial Plus Urinary Pain Relief
•Preferred Antibacterial Plus Urinary Pain Relief
•Urimar-T CAPS
•Urogesic BLUE

Show all 24

•Uretron D/S
•TopCare Antibacterial Plus Urinary Pain Relief
•Azo Urinary Tract Defense Antibacterial Protection
•CVS Antibacterial Plus Urinary Pain Relief
•CVS DUAL Action PAIN Relief
•Me NaPhos MB Hyo 1
•Uro-MP
•Walgreens Pain Relief plus UTI Bacteria Control
•Cystex
•Walgreens Antibacterial Plus Urinary Pain Relief
•MB CAPS
•D-30
•Urelle
•Rite Aid Antibacterial Plus Urinary Pain Relief
•Meijer Antibacterial Plus Urinary Pain Relief
•Good Neighbor Antibacterial Plus Urinary Pain Relief

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

Used in 9 sectors as 11 functional roles.

•Hardener in Plastics Product Manufacturing (100%)Processing as a reactant
•Chemical reaction regulator in Rubber Product Manufacturing (100%)Processing—incorporation into article
•Intermediate in Oil and Gas Drilling, Extraction, and Support activitiesProcessing as a reactant
•Catalyst in Mining (except Oil and Gas) and support activitiesProcessing as a reactant
•Intermediate in All Other Basic Organic Chemical ManufacturingProcessing as a reactant
•Polymerization promoter in Plastics Material and Resin Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
•Monomers in Plastics Material and Resin Manufacturing (10%)Processing as a reactant
•Processing aids, specific to petroleum production in Oil and Gas Drilling, Extraction, and Support activities (64%)Processing—incorporation into formulation, mixture, or reaction product
•Energy Releasers (explosives, motive propellant) in Explosives Manufacturing (20%)Processing—incorporation into formulation, mixture, or reaction product
•Binder in Primary Metal Manufacturing (100%)Processing—incorporation into article
•Terminator/Blocker in All Other Chemical Product and Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product
•Adhesion/cohesion promoter in Rubber Product Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.03/gALFA AESAR

CountryGermany

Pack$129.60 / 5 kg

Purity99%

Vendors12 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

11 more vendors

Vendor	Country	$/g	Pack	Purity
Sigma-Aldrich (Rush Stock)	Germany	$0.03	25 kg	100.5%
Sigma-Aldrich	Germany	$0.03	25 kg	100.5%
AK Scientific Specialized	United States	$0.12	500 g	95%
AK Scientific, Inc.	United States	$0.15	500 g	99%
Combi-Blocks, Inc.	United States	$0.25	1 kg	98%
Apexbio Technology LLC	United States	$17.00	5 g	98%
Interbioscreen	Hong Kong	$24.00	10 g	95%
MedKoo Biosciences, Inc	United States	$50.00	5 g	98%
Otava, Ltd.	Ukraine	$2280.00	50 mg	95%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	95%
Princeton BioMolecular Research (SC)	United States	$2900.00	100 mg	90%

Chemical Identity

CAS100-97-0

PubChem CID4101

DTXSIDDTXSID6020692

FormulaC6H12N4

Mol. Weight140.19 g/mol

SMILESC1N2CN3CN1CN(C2)C3

Data Sources

EPA CompTox (DSSTox) · DTXSID6020692Retrieved 2026-04-06
PubChem · compound 4101Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Methenamine (CAS 100-97-0) https://chemicalindependence.com/chemical/100-97-0/ EPA CompTox (DSSTox): DTXSID6020692. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID6020692 PubChem: 4101. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/4101 EPA Chemical Data Reporting: 100-97-0. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: CAS 100-97-0. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 293369 for CAS 100-97-0. Reporting year: 2024. https://usatrade.census.gov/