Cyclamic acid

Drug ingredient

CAS 100-88-9

Companies reported imports and no US production of this drug ingredient to EPA for 2023.

US productionZero

Import value, 2024$133M

Import volume276.8K lb

Import dependency100%

Top sourceChina 47%

Production is reported production, not a complete census of factories. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Cyclamic acid · US import value by year

2013: $68M · Peak 2022: $165M · 2024: $133M · 2025: $107M

Where It Comes From

Customs basis: HS 292990 · basket

EPA reports by year

2023: US production Zero · Imports 276.8K lb

These shares come from HS customs code 292990, which covers 38 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 47%ChinaDE 20%GermanyIN 14%IndiaGB 4%United KingdomKR 4%South Korea

Canada
Spain
Taiwan
Malaysia
Mexico
Ukraine
Netherlands
Russia
Latvia
Ireland
Australia
Sweden
Austria
Lithuania

EPA-registered importers (1)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

J&J Chemical

1 FDA-registered drug labeler

Professional Complementary Health Formulas

Why It Matters

Sectors

HealthConsumer Products

Downstream Uses

Appears in 1 drug and cosmetic product listings (FDA).

•Thio Combination 9306

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Cleaning agent in Soap, Cleaning Compound, and Toilet Preparation Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.23/gA2B Chem LLC

CountryUnited States

Pack$113.00 / 500 g

Purity98%

Vendors20 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

19 more vendors

Vendor	Country	$/g	Pack	Purity
AA BLOCKS	United States	$0.24	500 g	98%
Sigma-Aldrich (Rush Stock)	Germany	$0.46	500 g	98%
Sigma-Aldrich	Germany	$0.46	500 g	98%
BLD Pharmatech Ltd.	China	$0.60	500 g	98%
Combi-Blocks, Inc.	United States	$0.60	100 g	98%
Aaron Chemicals LLC	Hong Kong	$0.70	500 g	98%
AK Scientific, Inc.	United States	$0.70	100 g	98%
Angene Chemical	China → Hong Kong	$0.70	500 g	98%
Ambeed, Inc.	United States	$0.88	25 g	98%
AK Scientific Specialized	United States	$0.95	100 g	95%
AstaTech (2 weeks)	United States	$1.22	100 g	95%
Angene International Limited	United States	$1.43	100 g	98%
TargetMol Chemicals	China → United States	$64.00	1 g	99.92%
Molnova	China	$97.00	1 g	99%
MedChemExpress MCE	Sweden	$100.43	1 g	99.82%
Labotest KG	Germany	$453.00	1000 mg	90%
Apexbio Technology LLC	United States	$1000.00	50 mg	98%
Angene	China → Hong Kong	$4266.67	30 mg	98%
TimTec, LLC (back-ordered)	United States	$32000.00	15 mg	94%

Chemical Identity

CAS100-88-9

PubChem CID7533

DTXSIDDTXSID5041809

FormulaC6H13NO3S

Mol. Weight179.24 g/mol

SMILESC1CCC(CC1)NS(=O)(=O)O

Data Sources

PubChem · compound 7533Retrieved 2026-04-07
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
FDA National Drug Code directoryRetrieved 2026-04-07
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Cyclamic acid (CAS 100-88-9) https://chemicalindependence.com/chemical/100-88-9/ PubChem: 7533. Retrieved 2026-04-07. https://pubchem.ncbi.nlm.nih.gov/compound/7533 EPA Chemical Data Reporting: 100-88-9. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting FDA National Drug Code directory: bulk match. Retrieved 2026-04-07. https://open.fda.gov/data/ndc/ US Census international trade: HS 292990 for CAS 100-88-9. Reporting year: 2024. https://usatrade.census.gov/