Anisole

CAS 100-66-3

U.S. production volumes are classified as confidential business information.

US productionCBI

Confidential Business Information. The EPA withholds this volume because publishing it could reveal the reporting company's trade secrets.

Import value, 2024$59M

Top sourceChina 51%

At least one company claimed its 2023 production or import volume for this chemical as confidential, so EPA withholds it.

Why supply is unknown

Production is reported production, not a complete census of factories. US production volume is confidential. Production reporting year: 2023. Import value and source-country shares describe a shared customs category, not a separate chemical measurement.

Where It Comes From

Customs basis: HS 290930 · basket

EPA reports by year

2023: US production Confidential · Imports Confidential
2019: US production Confidential · Imports Confidential

These shares come from HS customs code 290930, which covers 119 tracked chemicals in total. They estimate the category's origin mix, not this chemical specifically.

Source Countries

Country of origin for US imports, from Census customs data (2024).

CN 51%ChinaIN 23%IndiaIT 12%ItalyJP 9%JapanCA 2%Canada

Spain
Israel
Netherlands
Taiwan
Germany
Ireland
Switzerland
Ukraine
Mexico
United Kingdom
Australia

EPA-registered importers (2)

Companies that report making or importing this chemical to the EPA. Registration is US-centric and does not indicate import origin.

Syensqo Sa · BE Belgium

Solvay

Why It Matters

Sectors

Electronics

Downstream UsesNot recorded

FDA Shortage Status

Whether any manufacturer currently reports this drug as in shortage on the FDA Drug Shortages database. "Active Shortage" means at least one presentation has status "current."

No FDA shortage records

Industrial Uses

•Solvent in Computer and Electronic Product Manufacturing (100%)Processing—incorporation into formulation, mixture, or reaction product

Vendor Pricing

$0.05/gA2B Chem LLC

CountryUnited States

Pack$24.00 / 500 g

Purity98%

Vendors12 available

Prices reflect listed pack sizes. Small research packs run far above bulk rates.

11 more vendors

Vendor	Country	$/g	Pack	Purity
Sigma-Aldrich (Rush Stock)	Germany	$0.05	10 kg	99%
Sigma-Aldrich	Germany	$0.05	10 kg	99%
AA BLOCKS	United States	$0.05	500 g	99%
ALFA AESAR	Germany	$0.06	2.5 kg	99%
AK Scientific Specialized	United States	$0.12	500 g	98%
AK Scientific, Inc.	United States	$0.16	500 g	99%
Combi-Blocks, Inc.	United States	$0.25	1 kg	98%
Labotest KG	Germany	$217.80	5000 mg	90%
ChemFaces	China	$1500.00	20 mg	98%
Otava, Ltd.	Ukraine	$2280.00	50 mg	95%
Otava, Ltd. (2 weeks)	Ukraine	$2724.00	50 mg	95%

Chemical Identity

CAS100-66-3

PubChem CID7519

DTXSIDDTXSID4041608

FormulaC7H8O

Mol. Weight108.14 g/mol

SMILESCOC1=CC=CC=C1

Data Sources

EPA CompTox (DSSTox) · DTXSID4041608Retrieved 2026-04-06
PubChem · compound 7519Retrieved 2026-04-06
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
EPA Chemical Data ReportingReporting year: 2023 · Retrieved 2026-10-04
US Census international tradeReporting year: 2024 · Retrieved 2026-10-04

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Brief citations

Anisole (CAS 100-66-3) https://chemicalindependence.com/chemical/100-66-3/ EPA CompTox (DSSTox): DTXSID4041608. Retrieved 2026-04-06. https://comptox.epa.gov/dashboard/chemical/details/DTXSID4041608 PubChem: 7519. Retrieved 2026-04-06. https://pubchem.ncbi.nlm.nih.gov/compound/7519 EPA Chemical Data Reporting: 100-66-3. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting EPA Chemical Data Reporting: CAS 100-66-3. Reporting year: 2023. https://www.epa.gov/chemical-data-reporting US Census international trade: HS 290930 for CAS 100-66-3. Reporting year: 2024. https://usatrade.census.gov/